Does preventing Hereditary Angioedema (HAE) attacks make you feel like one of these?

Join APeX-S, an open-label prospective clinical research study, for an investigational ORAL medication to prevent HAE attacks.

See if you are eligible for APeX-S, an open-label prospective clinical research study we are conducting testing an investigational oral medication to prevent HAE attacks.

The future could be a capsule rather than a needle to prevent HAE attacks.

Right now, patients are being enrolled in the
APeX-S study, a clinical research study evaluating the safety and effectiveness of an investigational oral medication that may prevent HAE attacks.

If you have HAE and are interested in learning about a potential alternative to injections or infusions to prevent attacks we invite you to see if you qualify.

If you’re interested in learning more about the APeX-S clinical research study and to see if you might qualify, please see locations below to find one of our research sites near you.
Am I Eligible?

If you are interested in participating in a clinical research study evaluating an investigational alternative to injections or infusions to prevent HAE attacks, you might be eligible if you:

  • Have been diagnosed with HAE Type 1 or 2
  • Are 12 years old or older
  • Have access to and can be treated
    with medicine for HAE attacks

All study-related medical care will be provided at no charge.

What should I know about participating in a clinical research study?

Thousands of people around the world participate in clinical research studies every year.

Only you can decide if a research study is right for you. You should only make your decision once you have learned about the clinical research study, have had all your questions answered, and have been thoroughly informed about the risks and benefits.

Participating in a clinical research study is purely voluntary. Should you decide to participate in the APeX-S study—or any clinical research study—you are free to withdraw at any time and for any reason.

You will be compensated for travel expenses and for your time spent at the clinic.


Clinical Research Center of Alabama

Massachusetts General Hospital

Bernstein Clinical Research Center

MaryCliff Clinical Research

Allergy and Asthma Clinical Research

Clinical Research of Charlotte

Institute for Asthma and Allergy

AARA Clinical Research

Medical Research of Arizona

Asthma and Allergy Associates, PC

Washington University

Deaconess Clinical, Inc.

Optimed Research, LTD

Little Rock Allergy & Asthma CRC

Austin Regional Clinic

Portland Clinical Research: Columbia Asthma and Allergy

University of Michigan Allergy Clinic

Allergy, Asthma & Immunology Associates of Tampa Bay

Allergy, Asthma & Immunology Associates PC

Atlanta Allergy & Asthma Clinic, PA

Asthma Research Institute

Asthma, Nasal Disease & Allergy Research Center Of New England

Seattle Allergy and Asthma Research Institute

Center for Allergy, Asthma & Immunology

Asthma Associates of Utah

Indiana University School of Medicine

Allergy & Asthma Medical Group and Research Center

IMMUNOe Research Centers

Kansas City Allergy

Western States Clinical Research, Inc.

Allergy and Asthma Clinic of Northwest Arkansas

Children's Hospital of Wisconsin

Mayo Clinic

Sneeze, Wheeze & Itch Associates

Duke Asthma, Allergy and Airway Center

Contact Us

If you are interested in learning more about the APeX-S trial, please submit the following information.

Important Resources

The HAE Association

Would you like the help of a fellow patient in finding the clinical trial site closest to you, or answering general questions about participating in clinical research? The US HAE Association (HAEA) — a non-profit patient advocacy organization founded and largely staffed by patients— stands ready to help you!

Feel free to call HAEA Senior Patient Advocate John Williamson at (972) 984-0621 or Please also visit the US Hereditary Angiodema Association website at: is a resource provided by the U.S. National Library of Medicine. It is a listing service of all active clinical trials in the USA.

Click this link to visit our study listing.